This topic contains 1 reply, has 1 voice, and was last updated by Mr A 6 months, 2 weeks ago.
25 January 2019 at 2:27 am #441
Many previously stable patients are finding it difficult to find a suitable alternative to fluphenazine. When a person has been on a high-potency medication for many years, secondary changes may take place in their brain which may make it difficult for other agents to successfully replace them. Dopamine receptor supersensitivity has been suggested as one such possible adaptation, and there is evidence that such adaptations may persist.
For one of my patients the fluphenazine was replaced with flupenthixol depot but these medications are quite dissimilar in their receptor activity. Fluphenazine is a phenothiazine compound, and it was known as a ‘high-potency’ agent, with strong antagonist activity at the D2 receptor compared to its effect on other receptor types due to a piperazine side chain at position 10. By contrast, flupenthixol is a thioxanthe compound and is a ‘low potency’ agent, and the sedative side effects comparatively outweigh the direct antipsychotic activity.
The closest related medication still obtainable (at least in Australia) would be periciazine (Neulactil), but this is still a lower potency agent with a piperadine side chain. An alternative would be to use an alternative high-potency agent such as the butyrophenone haloperidol which has a broadly similar receptor profile and is widely available, often as a depot agent. The risks of side effects such as movement disorders are not significantly higher than for the Modecate, and hopefully (apart from the risk of emergent tardive dyskinesia) can be managed with benztropine or similar agents. See below – M is for muscarinic receptor (cholinergic system).
Receptor Profile D2 5HT2 M A-1 adrenergic Antihistamine
Fluphenazine ++++ ++ + + ++
Haloperidol ++++ ++ + + +4 April 2019 at 3:23 pm #536
Thanks Angela, that’s very interesting information. Could you tell us a bit more about your expertise in this field or link to your profile anywhere? I think it would be useful for other users who want to talk about it to their consultant if they knew more about the source. Thanks!